Side Effects, Interactions, Warning, Dosage & Uses. WARNINGSIncluded as part of the PRECAUTIONS section. PRECAUTIONSHemorrhage. COUMADIN can cause major or fatal bleeding. Bleeding is. more likely to occur within the first month. Risk factors for bleeding include. INR > 4. 0), age greater than or equal to. INRs, history of gastrointestinal bleeding. Those at high risk of bleeding may benefit from more frequent INR. INR, and a shortest duration of. However, maintenance of INR in. Drugs, dietary changes, and other factors affect INR. COUMADIN therapy. Perform more frequent INR monitoring. Necrosis may be associated with local. COUMADIN. therapy. Aims of liver disease treatment. Liver disease encompasses a wide range of conditions and causes. In many cases the treatment of the condition is curative i.e. The cardiac diet is a healthy eating plan to follow, even if a person does not have any of these health conditions, and may be followed as a preventative management. In severe cases of necrosis, treatment through debridement or. Careful clinical evaluation is required to determine. Although various. Get the Coumadin Diet Plan and Cookbook! This indispensable book includes: 6 weeks of complete meal plans, with shopping lists; 95+ delicious Coumadin safe recipes. Discontinue COUMADIN therapy if necrosis occurs. Consider. alternative drugs if continued anticoagulation therapy is necessary. Calciphylaxis. Fatal and serious calciphylaxis or calcium uremic. When calciphylaxis is diagnosed in these patients, discontinue. COUMADIN and treat calciphylaxis as appropriate. Consider alternative. Systemic Atheroemboli And Cholesterol Microemboli. WebMD provides information about which foods to avoid while taking Coumadin Oral. MEDICATION GUIDE COUMADIN (COU-ma-din) (warfarin sodium) What is the most important information I should know about COUMADIN? COUMADIN can cause bleeding which can be. BLOOD THINNING WITH WARFARIN (COUMADIN) Warfarin is a compound of significant medical importance. Over the last 40 years, thousands have used it, and used it safely. HIGHLIGHTS OF PRESCRIBING INFORMATION These highlights do not include all the information needed to use COUMADIN safely and effectively. See full prescribing. If you take Coumadin, testing your PT/INR levels regularly is important. PT/INR Self Testing is fast and can be done at home or when you travel. Medicines can be effected by a patient’s diet so here are 10 foods to avoid while taking Coumadin. Foods high in Vitamin K can have a negative interaction with this. Anticoagulation therapy with COUMADIN may enhance the. Systemic atheroemboli and cholesterol. The most commonly involved visceral organs are the. Some cases have progressed. A distinct syndrome resulting from microemboli to the. Discontinue COUMADIN therapy if such. Consider alternative drugs if continued anticoagulation. Limb Ischemia, Necrosis, And Gangrene In Patients With HIT. And HITTSDo not use COUMADIN as initial therapy in patients with. HIT) and with heparin- induced. HITTS). Cases of limb ischemia. HIT and HITTS when. In some patients, sequelae have included amputation of the involved. Treatment with COUMADIN may be considered after the platelet. Use In Pregnant Women With Mechanical Heart Valves. COUMADIN can cause fetal harm when administered to a. While COUMADIN is contraindicated during pregnancy, the. COUMADIN may outweigh the risks for pregnant women. In those. individual situations, the decision to initiate or continue COUMADIN should be. COUMADIN exposure during pregnancy causes. If this drug is used during pregnancy, or if the. Hereditary or acquired deficiencies of protein C or. S, have been associated with tissue necrosis following. Concomitant anticoagulation therapy with heparin for 5. COUMADIN may minimize the incidence. Eye surgery: In cataract surgery, COUMADIN use was. As COUMADIN cessation or. COUMADIN before a relatively less invasive and complex eye surgery. Polycythemia vera. Vasculitis. Diabetes mellitus. Endogenous Factors Affecting INRThe following factors may be responsible for increased INR. K deficiency. The following factors may be responsible for decreased INR. K intake or hereditary warfarin resistance. Patient Counseling Information. Advise the patient to read the FDA- approved patient. Medication Guide). Instructions For Patients. Advise patients to: Strictly adhere to the prescribed dosage schedule . And to tell their physician if. Eat a normal, balanced diet to maintain a consistent. K. Avoid drastic changes in dietary habits, such as eating. Signs and symptoms of bleeding include: pain. COUMADIN can. cause fetal harm. Exposure to warfarin during the first trimester of pregnancy. Consider the benefits. COUMADIN and possible risks to the fetus when prescribing COUMADIN. In the U. S. Exposure to. Warfarin embryopathy is. Central nervous system and eye abnormalities have also been reported. Dandy- Walker malformation, midline cerebellar atrophy, and ventral. Mental retardation, blindness. Because of the potential. COUMADIN and any potential adverse effects on the. COUMADIN or from the underlying maternal condition before. COUMADIN to a lactating woman. Clinical Considerations. Monitor breastfeeding infants for bruising or bleeding. Data. Human Data. Based on published data in 1. Among the 1. 5 full- term newborns, 6 nursing. Prothrombin. times were not obtained for the other 9 nursing infants. Effects in premature. Females And Males Of Reproductive Potential. Pregnancy Testing. COUMADIN can cause fetal harm . Pediatric use of COUMADIN is. Pediatric patients. COUMADIN should avoid any activity or sport that may result in. The developing hemostatic system in infants and children results. Dosing. of warfarin in the pediatric population varies by patient age, with infants. INRs. Because of changing. INR ranges may be difficult to achieve and maintain. INR determinations are recommended. No overall differences in effectiveness or safety were. Patients 6. 0 years or older appear to exhibit greater than. INR response to the anticoagulant effects of warfarin . COUMADIN is contraindicated in any unsupervised patient with. Observe caution with administration of COUMADIN to elderly patients. Consider lower initiation and maintenance doses of COUMADIN in. No dosage adjustment is necessary for patients. Hepatic Impairment. Hepatic impairment can potentiate the response to. Use caution when using COUMADIN in these patients. REFERENCESOSHA Hazardous Drugs.
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